We have developed vehicle-carrier agents and bases that can penetrate the mucosa and cutaneous tissues and transport active ingredients to the treatment site. Several topical intraoral medications are used in the treatment of oral ulcerations and infections, including antifungals; nonsteroidal anti-inflammatory drugs (NSAIDs); and corticosteroids. Medicated lollipops, lozenges, and adhering powders can increase contact time with the mucosa.
An electrolyte tablet administered and retained intraorally a few minutes before the start of a procedure can suppress the gag reflex, allowing a mandibular block to be given with much greater ease, which further reduces the gagging reflex. Tablets can be prescribed for home use for patients who can not properly perform oral hygiene procedures due to the gagging problem. Some patients and dentists prefer to use electrolyte lollipops.
Topical application of anti-emetics in a gel formulation provides a rapid onset and offers an effective alternative to oral administration.
Transdermal application of NSAIDs such as ketoprofen results in significant tissue levels beneath the site of application. Additionally, side effects such as gastrointestinal irritation are avoided.
Compounding allows countless active ingredients to be incorporated into customized mouthwashes, gels, troches, etc. For example, to treat periodontal disease, antibiotics can be formulated as a mouthwash, or added to an oral adhesive paste or a plasticized gel that will maintain the contact between the tissue and medication for a longer period of time.
Compounding dental mouthwashes or rinses may offer numerous advantages over commercially available dosage forms. A customized preparation prepared using pharmaceutical grade powders can eliminate concerns of palatability, limit alcohol content, and eliminate dyes which may stain exposed mucosa. Various preparations are also available to treat burning mouth syndrome and anesthetic/analgesic and antibiotic/anti-infective mouthwashes are commonly requested.